Difluoromethyl-pyridin-2-yl triazoles
AssigneeBoehringer Ingelheim International GmbH
InventorsFlorian Montel, Yunhai Cui, Niklas Heine, Oliver Hucke, Radoslaw Michal Lipinski, Stefan Peters, Janus Schreiber Larsen
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Abstract
The present invention relates to difluoromethyl-pyridin-2-yl triazoles of general formula (I) which are modulators of GABAA receptors containing the α5 subunit, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for the manufacture of compounds according to the invention.
Claims22
A compound or a salt thereof, having the formula:
- wherein:
- Xa and Xb are different from each other and represent C or N and
- R1 is unsubstituted 2-pyridon or 2-pyridon substituted with halogen, methyl, or ethyl.
(canceled)
4-10. (canceled)
12-14. (canceled)
(canceled)
A compound, or a salt thereof, having formula
- wherein:
- Xa and Xb are different from each other and represent C or N, and
- R1 is selected from the group consisting of:
- phenyl substituted with carbamoyl;
- 2, 3 or 4-pyridyl substituted with cyano- (NC—), thiomethylate-, amino-, methyl-amino-, methylsulfonyl-, or halogen;
- unsubstituted pyrimidinyl- or pyrimidinyl-substituted with C1-6-alkyl-, amino-, -hydroxymethyl-, pyrazinyl- or pyridazinyl;
- imidazolyl-substituted with C1-6-alkyl-, carbamoyl-, NC—CH2—CH2—, amino- or -methylamino-;
- unsubstituted triazolyl- or triazolyl-substituted with C1-3-alkyl-;
- and
- oxazolyl-substituted with methyl or thiophenyl-substituted with NC—CH2—CH2—.
A compound, or a salt thereof, having formula
- wherein:
- Xa and Xb are different from each other and represent C or N, and
- R1 is selected from the group consisting of:
- a) pyrrolyl-substituted with C1-6-alkyl- or NC—CH2—CH2—;
- c) pyrazolyl-substituted with C1-6-alkyl-, C3-5-cycloalkyl-, NC—CH2—CH2—, -amino, -methyl-amino, or -halogen;
- and
Dependencies are inferred from the claim text.