Biphenyl compound, pharmaceutical composition, method for preparing same, and use thereof
AssigneeLongivitron (Suzhou) Biotechnology Co., Ltd
InventorsXiaoyu LIU, Xiaoguang CHEN, Yan LI, Xiaoxi ZHANG, Yanshi ZHAO
Life of this patent
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Abstract
Provided are a biphenyl compound, a pharmaceutical composition, a method for preparing same, and use thereof. The biphenyl compound has a structure represented by formula I. The provided biphenyl compound can have relatively good binding to multiple target proteins, has relatively good bioavailability, and can be used for preparing drugs for preventing or treating tumors, autoimmune diseases, inflammatory diseases, and neurodegenerative diseases or anti-aging drugs.
Claims16
A biphenyl compound, having a structure represented by Formula I:
- wherein R1 and R2 are each independently selected from any one of hydrogen, halogen, hydroxy, dimethylamino, cyano, nitro, C1-C8 alkoxycarbonyl, C1-C8 alkylcarbonyloxy, methylamino, methanesulfonyl, dimethylaminesulfonyl, amino, carboxyl, C1-C8 alkyl, C1-C8 alkoxy, C1-C8 trihaloalkyl, C1-C8 trihaloalkoxy, C1-C8 alkoxymethyleneoxy, C1-C8 methoxymethyleneoxy, cyclopentyloxy or cyclohexyloxy;
- n is selected from 0, 1, 2, 3 or 4;
- X is selected from CH2, O or NH;
- Y is selected from any one of CH2, O, OH, NH, NH2, NH(CH2)n·NH2, NH(CH2)n·NHCOCF3, OBn, C1-C8 alkyl, C1-C8 alkoxy, trihalomethylamino, dimethylamino, methylamino or trihaloalkoxy;
- wherein n′ is selected from 1, 2, 3, 4 or 5;
- M is selected from any one of CH2, O, OH, NH, NH2, trihalomethylamino, trihalomethylacyl, dimethylamino, methylamino, carboxyl, trihaloalkyl or C1-C8 alkoxymethyleneoxy;
- and
- M is joined to Y by a bond or M does not form a bond with Y.
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Dependencies are inferred from the claim text.