# US 2026/0295264 A1 · Stimulation-evoked signal type determination for stimulation therapy

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- Number: US 2026/0295264 A1
- Document ID: US20260295264A1
- Status: Published application
- Kind: A1
- Application number: 19/478,640
- Filed: 2024-04-03
- Published: 2026-10-01
- Earliest claimed: 2023-04-25
- Assignees: Medtronic, Inc.
- Applicants: Medtronic, Inc.
- Inventors: Julia P. Slopsema; Hank T. Bink; Abigail L. Skerker; Simeng Zhang; Sarah J. Offutt; Leonid M. Litvak
- Web page: https://patentgrep.com/patent/US20260295264A1

## CPC

- A61N 1/36139: {with automatic adjustment}
- A61N 1/36007: {of urogenital or gastrointestinal organs, e.g. for incontinence control}
- A61N 1/36171: {Frequency}
- A61N 1/36175: {Pulse width or duty cycle}
- A61N 1/36185: {Selection of the electrode configuration}
- A61N 1/37235: {Aspects of the external programmer}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

An example method includes determining, for a patient, characteristics of one or more different signal types that are received in response to using at least one setting selected from the group of one or more electrical stimulation settings, one or more sensing settings, or combinations thereof. The example method also includes programming neurostimulation system, based on the characteristics, at least one of: electrical stimulation settings for delivering subsequent electrical stimulation to a patient for evoking at least one of the signal types, or sensing settings for sensing at least one of the signal types in response to stimulation of the patient.

## Claims

### Claim 1

A system comprising:
at least one electrode configured to deliver the electrical stimulation to a patient; and
a device comprising processing circuitry configured to:
determine, for a patient, characteristics of one or more different signal types that are received in response to using at least two settings selected from the group of one or more electrical stimulation settings, one or more sensing settings, or combinations thereof; and
program a neurostimulation system, based on the characteristics, at least one of:
electrical stimulation settings for delivering subsequent electrical stimulation to a patient for evoking at least one of the signal types, or
sensing settings for sensing at least one of the signal types in response to stimulation of the patient.

### Claim 2 (depends on 1)

The system of claim 1, wherein the processing circuitry is further configured to:
at least one of deliver, according to the determined electrical stimulation settings, the subsequent electrical stimulation to the patient to evoke the one or more subsequent stimulation-evoked signals from the patient, or sense, according to the determined sensing settings, the one or more subsequent stimulation-evoked signals from the patient in response to the subsequent electrical stimulation.

### Claim 3 (depends on 1)

The system of claim 1, wherein the processing circuitry is further configured to deliver therapeutic electrical stimulation based on the one or more subsequent stimulation-evoked signals.

### Claim 4 (depends on 1)

The system of claim 1, wherein the one or more different signal types comprise at least one of an evoked neural signal type, an electromyography (EMG) signal type, or a composite evoked neural signal type signal type and EMG signal type.

### Claim 5 (depends on 1)

The system of claim 1, wherein the characteristics comprise one or more signal features comprising at least one of a signal peak, a signal peak amplitude, a number of signal peaks, an area under signal peaks, a signal peak width, a time between signal peaks, a ratio of signal peak amplitudes, a ratio of signal peak widths, a ratio of areas under signal peaks, a latency of a signal peak, a signal valley, a signal valley amplitudes, a number of signal valleys, an area above a signal valley, a signal valley width, a time between signal valleys, a ratio of signal valley amplitudes, a ratio of signal valley widths, a ratio of areas above signal valleys, a valley latency, a root-mean-square signal value, a signal skew, a signal kurtosis, a signal frequency, a signal spectral content, a Hjorth feature, a signal amplitude growth curve threshold, a signal amplitude growth curve inflection point amplitude, a signal amplitude growth curve inflection point latency, a signal amplitude growth curve saturation point, a signal strength duration curve feature, a signal maximum rate of change, or a signal minimum rate of change.

### Claim 6 (depends on 1)

The system claim 1, wherein the electrical stimulation settings comprise settings for delivering subsequent electrical stimulation configured to at least one of:
evoke an ECAP signal,
evoke an EMG signal,
evoke a composite ECAP and EMG signal,
evoke an ECAP signal followed by an EMG signal, or
evoke an EMG signal followed by an ECAP signal.

### Claim 7 (depends on 6)

The system of claim 6, wherein the processing circuitry is configured to determine characteristics of the two or more different signal types by:
sweeping through a delivery of a plurality of electrical stimulation pulses, wherein each electrical stimulation pulse is characterized by at least an electrode configuration, a pulse width, a polarity, a frequency, an amplitude, a recharge parameter, or a pulse pattern; and
sweeping through sensing parameters to sense one or more stimulation-evoked signals, wherein the one or more sensing parameters comprises an electrode configuration or a blanking parameter.

### Claim 8 (depends on 7)

The system of claim 7, wherein each sensed stimulation-evoked signal of the two or more different signal types is sensed after a corresponding electrical stimulation pulse or a set of corresponding stimulation pulses of the plurality of electrical stimulation pulses.

### Claim 9 (depends on 7)

The system of claim 7, wherein the plurality of electrode configurations comprises at least one of a monopolar configuration, a bipolar configuration, or a tripolar configuration, and
wherein the plurality of pulses comprises a pulse that is at least 20 microseconds and less than or equal to 450 microseconds.

### Claim 10 (depends on 1)

The system of claim 1, wherein the electrical stimulation settings for delivering subsequent electrical stimulation to a patient for evoking at least one of the signal types comprises a masker-probe pulse sequence.

### Claim 11 (depends on 2)

The system of claim 2, wherein the electrical stimulation settings for delivering subsequent electrical stimulation to a patient for evoking at least one of the signal types comprises alternating the polarity of consecutive pulses.

### Claim 12 (depends on 2)

The system of claim 2, wherein the characteristics are first characteristics, wherein the electrical stimulation settings are first electrical stimulation settings, wherein the sensing settings are first sensing settings, wherein the processing circuitry is further configured to:
determine, for the patient, second characteristics of two or more different signal types that are received in response to using at least two settings selected from the group of one or more electrical stimulation settings, one or more sensing settings, or combinations thereof;
program the neurostimulation system, based on the second characteristics, to include at least one of:
second electrical stimulation settings for delivering subsequent electrical stimulation to a patient for evoking at least one of the signal types, or
second sensing settings for sensing at least one of the signal types in response to stimulation of the patient; and
at least one of deliver, according to the determined second electrical stimulation settings, the subsequent electrical stimulation to the patient to evoke the one or more subsequent stimulation-evoked signals from the patient, or sense, according to the second signal sensing settings, the one or more subsequent stimulation-evoked signals from the patient in response to the subsequent electrical stimulation.

### Claim 13

A computer readable medium comprising instructions that when executed cause one or more processors to:
determine, for a patient, characteristics of one or more different signal types that are received in response to using at least two settings selected from the group of one or more electrical stimulation settings, one or more sensing settings, or combinations thereof; and
program a neurostimulation system, based on the characteristics, at least one of:
electrical stimulation settings for delivering subsequent electrical stimulation to a patient for evoking at least one of the signal types, or
sensing settings for sensing at least one of the signal types in response to stimulation of the patient.
