Baroreflex activation therapy for the treatment of secondary pulmonary hypertension

Abstract

This disclosure presents systems and methods for treating secondary pulmonary hypertension (PH) using baroreflex activation therapy (BAT). A stimulation device delivers electrical stimulation to a baroreceptor to modulate autonomic nervous system activity and reduce pulmonary vascular resistance and right ventricular afterload. Pulmonary arterial pressure is measured using one or more pressure sensors, and stimulation parameters are automatically adjusted based on the measured pressure. In certain embodiments, a closed-loop control algorithm regulates stimulation intensity using pulmonary arterial pressure and additional physiological parameters, including right atrial or systemic arterial pressure. Therapy parameters may be adjusted during rest and exercise states and selected based on a dose-response relationship between stimulation intensity and pulmonary pressure reduction. Historical pulmonary pressure data may be used to predict future pressure trends and refine therapy delivery. These adaptive systems provide physiologically guided management of secondary PH through autonomic modulation.

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