Devices and methods for puncturing a capsule to release a powdered medicament therefrom

A punctured capsule, comprising:

• opposing domes and a cylindrical wall portion defined by a radius r, at least one dome being punctured with at least one hole, a center of each hole located within an annular region situated at no less than 0.4 r,
• wherein a total surface area of all puncture holes is between about 0.5% and about 2.2% of a total surface area of the capsule.

A method for puncturing a capsule to release a powdered medicament therefrom, the method comprising:

• receiving, within a chamber, a capsule comprising opposing domes and a cylindrical wall portion defined by a capsule wall radius r;
• and
• puncturing at least one hole in at least one dome, a center of each hole located within an annular puncture region situated at no less than 0.4 r, wherein a total surface area of all puncture holes is between about 0.5% and about 2.2% of a total surface area of the capsule.