# US 2026/0295153 A1 · Device for subcutaneous delivery of fluid medicament

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2026/0295153 A1
- Document ID: US20260295153A1
- Status: Published application
- Kind: A1
- Application number: 19/707,857
- Filed: 2026-06-15
- Published: 2026-10-01
- Earliest claimed: 2017-07-07
- Assignees: NeuroDerm, Ltd.
- Applicants: NeuroDerm, Ltd.
- Inventors: Eran Shor; Tsabar Mor; Tamir Ben David; Nir Lilach; Rami Grossfeld; Shai Alfandari; Ram Nadler; Dmitry Golom; Daniel Shaki; Yoav Tikochinsky; Serdar Ozsumer
- Web page: https://patentgrep.com/patent/US20260295153A1

## CPC

- A61M 5/14248: {of the skin patch type}
- A61J 1/2003: {Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting}
- A61J 1/2013: {having two piercing ends}
- A61M 5/1407: {Infusion of two or more substances}
- A61M 5/1413: {Modular systems comprising interconnecting elements}
- A61M 5/14216: {Reciprocating piston type}
- A61M 5/1456: {with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir}
- A61M 5/1723: {using feedback of body parameters, e.g. blood sugar or pressure}
- A61M 5/1782: {Devices aiding filling of syringes in situ (combination of a vial and a syringe for transferring or mixing their contents A61J1/2096, filling of medical containers in general B65B3/003)}
- A61M 5/31528: {by means of rotational movements, e.g. screw-thread mechanisms}
- A61M 5/345: {Adaptors positioned between needle hub and syringe nozzle}
- H03H 9/0509: {consisting of adhesive elements}
- H03H 9/0585: {consisting of an adhesive layer}
- H03H 9/54: comprising resonators of piezoelectric or electrostrictive material (comprising resonators using surface acoustic waves H03H9/64)
- H03H 9/64: using surface acoustic waves
- A61M 2005/14252: {with needle insertion means}
- A61M 2005/14268: {with a reusable and a disposable component}
- A61M 2005/14506: {mechanically driven, e.g. spring or clockwork}
- A61M 2005/14573: {with a replaceable reservoir for quick connection/disconnection with a driving system}
- A61M 2005/1586: {Holding accessories for holding infusion needles on the body}
- A61M 2005/1726: {the body parameters being measured at, or proximate to, the infusion site}
- A61M 2005/3125: {Display means, e.g. to indicate dose setting}
- A61M 2202/0468: non-physiological
- A61M 2205/13: with means for the detection of operative contact with patient, e.g. lip sensor
- A61M 2205/33: Controlling, regulating or measuring
- A61M 2205/50: with microprocessors or computers
- A61M 2205/8206: battery-operated
- A61M 2210/04: Skin
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- H03H: IMPEDANCE NETWORKS, e.g. RESONANT CIRCUITS; RESONATORS (waveguides, resonators, lines or other devices of the waveguide type H01P)

## Abstract

An improved device delivers a fluid medicament to the subcutaneous tissue of a user. The device is better suited for patients with Parkinson's Disease and other central nervous system disorders, than conventional infusion devices. The device can include a reusable part including a drive component (e.g., motor) and control electronics and a disposable part including a medicament reservoir. Medicament can be evacuated from the medicament reservoir by a plunger assembly that includes a plunger attached to a lead screw that is rotated by a nut, all within the disposable part. The device can be fluidically coupled with the tissue via a flexible cannula. Various embodiments relate to an improved cannula insertion mechanism that delivers the cannula under a force applied by a spring. Various embodiments relate to improved filling of the device, for example, using a vial adapter and an automated filling station.

## Claims

### Claim 1

A device for delivering a fluid medicament into or through the skin of a user, the device comprising:
a reusable part comprising:
a drive component; and
a control unit for controlling the drive component; and
a disposable part engageable with the reusable part, the disposable part comprising:
a first reservoir for containing the fluid medicament, wherein the first reservoir comprises a first bushing;
a first plunger head moveable by a first lead screw in the first reservoir; and
a first nut concentrically secured by and rotatable in the first bushing, the first nut threadedly engaged with a thread of the first lead screw, wherein the first bushing comprises a first compliant portion that permits the first nut a degree of lateral freedom of movement, and wherein the first nut is configured to be detachably coupled with and rotatable by the drive component upon engaging the reusable part with the disposable part and while the reusable part is engaged with the disposable part, and wherein the first nut is configured, upon rotation of the first nut in the first bushing, to linearly displace the first lead screw in a direction dependent on a rotation direction of the first nut.

### Claim 2 (depends on 1)

The device of claim 1, wherein the disposable part further comprises:
a second reservoir for containing additional fluid medicament, wherein the second reservoir comprises a second bushing;
a second plunger head for driving the additional fluid medicament out of the second reservoir, the second plunger head moveable in the second reservoir by a second lead screw; and
a second nut concentrically secured by and rotatable in the second bushing, the second nut threadedly engaged with a thread of the second lead screw, wherein the second bushing comprises a second compliant portion that permits the second nut a degree of lateral freedom of movement, and wherein when the reusable part and the disposable part are attached, the second nut is operably coupled with and rotatable by the drive component in a direction controllable by the control unit, and wherein the second nut is configured, upon rotation of the second nut in the second bushing, to linearly displace the second lead screw in a direction dependent on a rotation direction of the second nut.

### Claim 3 (depends on 1)

The device of claim 1, wherein the first nut comprises a first circumferential groove formed by a first circumferential ledge and a second circumferential ledge spaced apart from the first circumferential ledge, wherein the first bushing secures the first nut via the first compliant portion of the first bushing adapted to fit within the first circumferential groove of the first nut.

### Claim 4 (depends on 3)

The device of claim 3, wherein each of the first circumferential groove and the first compliant portion comprises a rounded profile.

### Claim 5 (depends on 3)

The device of claim 3, wherein a cross-section perpendicular to a first longitudinal axis of the first nut through the first compliant portion and the first circumferential groove forms two complete concentric circles.

### Claim 6 (depends on 3)

The device of claim 3, wherein the fluid medicament in the first reservoir comprises levodopa or carbidopa, or a combination of levodopa and carbidopa.

### Claim 7

A disposable part for containing fluid medicament for delivery by a fluid medicament delivery device into or through the skin of a user, the disposable part comprising:
a first reservoir for containing the fluid medicament;
a first plunger head moveable by a first lead screw in the first reservoir;
a first bushing disposed in the first reservoir; and
a first nut concentrically secured by and rotatable in the first bushing, wherein the first bushing comprises a first compliant portion that permits the first nut a degree of lateral freedom of movement, the first nut threadedly engaged with the first lead screw to linearly displace the first lead screw in the first reservoir in a direction dependent on a rotation direction of the first nut in the first bushing.

### Claim 8 (depends on 7)

The disposable part of claim 7, further comprising:
a second reservoir for containing an additional fluid medicament;
a second plunger head moveable by a second lead screw in the second reservoir;
a second bushing disposed in the second reservoir; and
a second nut concentrically secured by and rotatable in the second bushing, wherein the second bushing comprises a second compliant portion that permits the second nut a degree of lateral freedom of movement, the second nut threadedly engaged with the second lead screw to linearly displace the second lead screw in the second reservoir in a direction dependent on a rotation direction of the second nut in the second bushing.

### Claim 9 (depends on 7)

The disposable part of claim 7, where the fluid medicament delivery device comprises a reusable part, and wherein the first nut is configured to be operably coupled with and rotatable by a drive component of the reusable part upon engaging the disposable part with the reusable part and while the disposable part is engaged with the reusable part.

### Claim 10 (depends on 7)

The device of claim 7, wherein the first nut comprises a first circumferential groove formed by a first circumferential ledge and a second circumferential ledge spaced apart from the first circumferential ledge, wherein the first bushing secures the first nut via the first compliant portion of the first bushing adapted to fit within the first circumferential groove of the first nut.

### Claim 11 (depends on 10)

The disposable part of claim 10, wherein each of the first circumferential groove and the first compliant portion comprises a rounded profile.

### Claim 12 (depends on 10)

The disposable part of claim 10, wherein a cross-section perpendicular to a first longitudinal axis of the first nut through the first compliant portion and the first circumferential groove forms two complete concentric circles.

### Claim 13 (depends on 10)

The device of claim 10, wherein the fluid medicament in the first reservoir comprises levodopa or carbidopa, or a combination of levodopa and carbidopa.

### Claim 14

A reservoir for containing fluid medicament for delivery into or through the skin of a user by a fluid medicament delivery device comprising a reusable part, the reservoir engageable with the reusable part and comprising:
a plunger head moveable by a lead screw in the reservoir;
a bushing disposed in the reservoir; and
a nut concentrically secured by and rotatable in the bushing, wherein the bushing comprises a compliant portion that permits the nut a degree of lateral freedom of movement, the nut threadedly engaged with the lead screw to linearly displace the lead screw in the reservoir in a direction dependent on a rotation direction of the nut in the bushing.

### Claim 15 (depends on 14)

The reservoir of claim 14, wherein the nut is configured to be operably coupled with and rotatable by a drive component of the reusable part upon engaging the reservoir and the reusable part and while the reusable part is engaged with the reservoir.

### Claim 16 (depends on 14)

The reservoir of claim 14, wherein the nut comprises a circumferential groove formed by a first circumferential ledge and a second circumferential ledge spaced apart from the first circumferential ledge, wherein the bushing secures the nut via the compliant portion of the bushing adapted to fit within the circumferential groove.

### Claim 17 (depends on 16)

The reservoir of claim 16, wherein the circumferential groove and the compliant portion each comprises a rounded profile.

### Claim 18 (depends on 16)

The reservoir of claim 16, wherein a cross-section perpendicular to a longitudinal axis of the nut through the compliant portion and the circumferential groove forms two complete concentric circles.

### Claim 19 (depends on 14)

The device of claim 14, wherein the fluid medicament to be contained in the reservoir comprises levodopa or carbidopa, or a combination of levodopa and carbidopa.