US 2026/0295137 A1 · METHOD FOR REMOVING UREMIC TOXINS FROM BLOOD

Method for removing uremic toxins from blood

AssigneesInstitut National de la Sante et de la Recherche Medicale, Universite Claude Bernard Lyon 1, Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement, Hospices Civils De Lyon

InventorsChristophe SOULAGE, Fitsum GUEBRE-EGZIABER, Nans FLORENS

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Abstract

The invention relates to a method for removing uremic toxins bound to a protein from the blood of a patient in need thereof. The method comprises the introduction in the blood of a displacer substance chosen from (C6-C12)-fatty acids, salts of (C6-C12)-fatty acids, a precursor of said (C6-C12)-fatty acids, or mixtures thereof. The displacer substance replaces the uremic toxins bound to the protein, thereby releasing unbound uremic toxins in the blood. The unbound uremic toxins are then removed from the blood by any method of dialysis. The method according to the invention involves low concentrations of displacer substance and is effective at plasma concentrations comprised in the range of from 1 μM to 3 mM.

Claims21

Dependent claims

A method for removing uremic toxins bound to a protein from the blood of a patient in need thereof, the method comprising the steps of:

a) Introducing a displacer substance in the blood, under conditions in which the displacer substance replaces the uremic toxins bound to the protein, thereby releasing unbound uremic toxins in the blood,
b) Removing the unbound uremic toxins from the blood by dialysis,
the displacer substance being chosen from (C6-C12)-fatty acids, salts of (C6-C12)-fatty acids, a precursor of said (C6-C12)-fatty acids or mixtures thereof,
the displacer substance being provided in the blood at a plasma concentration comprised in the range of from 1 μM to 3 mM, in particular of from 0.5 to 3 mM.

1 more element

Dependencies are inferred from the claim text.