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US 2026/0295129 A1Published application
Self-assembling peptide hydrogels for treatment of fistulas
AssigneeGel4Med, Inc.
InventorManav Mehta
Life of this patent
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Abstract
Methods of treating fistulas are disclosed. The methods include administering a preparation comprising a purified amphiphilic peptide in an aqueous biocompatible solution and administering a buffer to a target site within a cavity of the fistula. The peptide has a folding group having a plurality of charged amino acid residues and hydrophobic amino acid residues arranged in a substantially alternating pattern. The peptide is configured to self-assemble into a hydrogel.
Claims37
A method of treating a fistula in a subject, comprising:
- administering to a target site within a cavity of the fistula a preparation comprising a purified amphiphilic peptide in an aqueous biocompatible solution, the peptide comprising a folding group having a plurality of charged amino acid residues and hydrophobic amino acid residues arranged in a substantially alternating pattern, the peptide being configured to self-assemble into a hydrogel, in an amount effective to treat the fistula;
- and
- administering to the target site a buffer configured to induce self-assembly of the peptide into the hydrogel.
Dependencies are inferred from the claim text.