Devices and methods for preparing and conditioning biological assemblies for minimally invasive delivery for tissue engineering, cell therapies and other therapeutic applications
AssigneeVolumina Medical SA
InventorsAmélie BÉDUER, Thomas BRASCHLER
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Abstract
The sterile container, preferably in form of a syringe, has an oxygen and/or carbon dioxide permeability of at least 0.1 mL/Pa/m2/day and is provided with at least one fluidic port permitting sterile connection to other containers and/or tubes, containing a porous, biocompatible polymer-based biomaterial with at least 30% porosity, preferentially at least 50% porosity, and most preferentially at least 80% porosity. This has the advantage of enabling intraoperative conditioning, circumventing the need for cell culture facilities, while still achieving targeted conditioning.
Claims22
1-56. (canceled)
A sterile container, wherein:
- (i) the container has an oxygen and/or carbon dioxide permeability of at least 0.1 mL/Pa/m2/day;
- (ii) the container has at least one fluidic port permitting sterile connection to other containers and/or tubes;
- (iii) the container contains a porous, biocompatible polymer-based biomaterial with at least 30% porosity;
- (iv) the porous biomaterial has a pore size of between 20 micrometers and 2 mm;
- (v) the porous biomaterial has a Young's modulus of 50 Pa to 50 kPa;
- and
- (vi) the porous biomaterial is reversibly compressible by at least a factor of 2.
Dependencies are inferred from the claim text.