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AssigneeAroa Biosurgery Limited
InventorsBrian WARD, Matthew SMITH, Roderick STANLEY, Bamaby MAY, Aaron SMITH, Mansura Aziza-ara KHAN, Micheal JERRAM, Isaac MASON, Sandi DEMPSEY
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This invention and disclosure relate to compositions and medical products comprising extracellular matrix (ECM) tissue, for example comminuted or particulate ECM tissue, for use in therapy, for example for use in tissue grafts, wound repair, and tissue repair. Also described are methods of manufacturing such compositions and medical products to provide medical products having desired physical and/or physiological properties. Particularly contemplated examples include compositions and medical products comprising comminuted or particulate ECM tissues, such as forestomach tissue such as that isolated from animal donors, for application to wounds or tissues in need of repair, and which conform to or occupy at least a part of the volume of such wounds or tissues in need of repair.
A composition comprising particulate extracellular matrix tissue, wherein the particulate extracellular matrix tissue comprises particles comprising, consisting essentially of, or consisting of extracellular matrix tissue, wherein said particles have an irregular shape and are capable of physically interacting with one another so as to resist movement relative to one another.
The composition of any one of the preceding claims, wherein the irregular shape, the physical interaction, the entanglement, and/or the agglomeration contributes to the adoption and/or maintenance of a three-dimensional network of said particles.
The composition of any one of the preceding claims, wherein the composition adopts and/or maintains a self-supporting three-dimensional network of said particles.
The composition of any one of the preceding claims, wherein when in the presence of moisture, and when entangled or agglomerated or wherein when present as a three-dimensional network, the particles entrap air.
The composition of any one of the preceding claims wherein when entangled or agglomerated or wherein when present as a three-dimensional network at least about 5% by volume of the entangled or agglomerated particles or of the three-dimensional network of particles is void space.
The composition of any one of the preceding claims, wherein the particles adsorb moisture.
The composition of any one of the preceding claims, wherein a plurality of the particles has a high angle of repose.
The composition of any one of the preceding claims, wherein there is a high degree of physical non-uniformity across a population of the particles.
The composition of any one of the preceding claims, wherein the physical non-uniformity is non-uniformity of size, non-uniformity of shape, non-uniformity of aspect ratio, or any combination of two or more thereof.
The composition of any one of the preceding claims, wherein one or more of said particles comprises, consists essentially of, or consists of one or more fibrillar processes.
The composition of any one of the preceding claims, wherein one or more of said particles comprises, consists essentially of, or consists of one or more fibrillar processes projecting in more than one plane.
A composition comprising comminuted extracellular matrix tissue, wherein the comminuted extracellular matrix tissue:
The composition of any one of the preceding claims, wherein the comminuted extracellular matrix tissue particles have or the particulate extracellular matrix tissue has a distribution of particle sizes wherein at least about 25% of the particles have a surface area of from about 0.25 mm2 to about 1 mm2.
The composition of any one of the preceding claims, wherein the comminuted extracellular matrix tissue particles have or the particulate extracellular matrix tissue has a distribution of particle sizes wherein at least about 25% of the particles have a surface area of from about 1 mm2 to about 2 mm2.
The composition of any one of the preceding claims, wherein the comminuted extracellular matrix tissue particles are or the particulate extracellular matrix tissue is able to sequester and/or adsorb water in a mass ratio greater than 5:1 (water:particle).
The composition of any one of the preceding claims, wherein the comminuted extracellular matrix tissue particles have or the particulate extracellular matrix tissue has a ratio of bulk density:material density of less than 0.7:1.
The composition of any one of the preceding claims, wherein the comminuted extracellular matrix tissue particles have or the particulate extracellular matrix tissue has a distribution of particle size by surface area having:
A medical product comprising a composition comprising the comminuted extracellular matrix tissue particles or the particulate extracellular matrix tissue as claimed in any one of the preceding claims together with a pharmaceutically acceptable carrier.
A method of preparing a tissue graft composition, the method comprising:
The composition, medical product, method, or use of any one of the preceding claims, wherein the extracellular matrix tissue is from a ruminant.
The composition, medical product, method, or use of any one of the preceding claims, wherein the extracellular matrix tissue is ovine forestomach or bovine placenta, or a combination of both.
The composition, medical product, method, or use of any one of the preceding claims, wherein the composition further comprises a biocompatible material, a cell, a drug, a growth factor, or an antibiotic.
The composition, medical product, method, or use of any one of the preceding claims, wherein the extracellular matrix tissue is a non-dialyzed and/or a non-lyophilised extracellular matrix tissue.
The composition, medical product, method, or use of any one of the preceding claims, wherein the composition transitions to an aggregated or gel form on administration to a wound or tissue.
The composition, medical product, method, or use of any one of the preceding claims, wherein the composition is injectable through a needle.
The composition, medical product, method, or use of any one of the preceding claims, wherein the composition is injectable through a needle, such as an 18-gauge needle.
The use of a composition or product of any one of the preceding claims for replacing or repairing tissue in a subject in need thereof.
Dependencies are inferred from the claim text.