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US 2026/0295072 A1Published application
Polymer nanoparticle compositions for non-viral gene delivery
AssigneeBattelle Memorial Institute
InventorsAndrea D. McCue, Ashlee J. Colbert, Molly Kaufman, Danielle J. Huk, Kenneth R. Sims, Jr., Emma K. Schmitz, Dean Constantine
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Abstract
The disclosure relates to block copolymer nanoparticles for in vivo screening and for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering circRNA.
Claims20
A composition comprising:
- a polymer nanoparticle comprising a block copolymer, and
- a circular RNA complexed to the polymer nanoparticle, wherein the ratio by weight of the nanoparticle to the circular RNA is about 1:1 to about 20:1, and
- wherein the block copolymer comprises:
- a first block comprising a monomer unit represented by formula I:
- or a salt thereof, wherein:
- p is 0 or an integer selected from 1-3,
- each R1 is individually selected from H or alkyl;
- and
- wherein each * represents a connecting point to the rest of the block copolymer;
- and
- a second block comprising a copolymer of monomer units selected from formula II:
- or a salt thereof, wherein:
- X is —O—;
- R2 is alkyl;
- and
- R3 is alkyl;
- wherein each * represents a connecting point to the rest of the block copolymer;
- and
- formula III:
- or a salt thereof, wherein:
- R4 is alkyl;
- wherein each * represents a connecting point to the rest of the block copolymer.
19 more elements
Dependencies are inferred from the claim text.