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US 2026/0295067 A1Published application
Panras inhibitor antibody-drug conjugates and methods of use thereof
AssigneeNovartis AG
InventorsMatthew T. BURGER, Joseph Anthony D'ALESSIO, Kathleen Tian XIE
Life of this patent
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Abstract
Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise a panRAS inhibitor drug moiety. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising panRAS inhibitor drug moiety and methods of making same are also disclosed.
Claims115
An antibody-drug conjugate of Formula (1):
- wherein Ab is an antibody or an antigen-binding fragment thereof;
- L is a conjugate linker that covalently attaches Ab to D;
- p is an integer from 1 to 16;
- and
- D is a panRAS inhibitor.
2 more elements
Dependencies are inferred from the claim text.