Broad-spectrum antibiotic hybrids for the treatment of multi-drug resistant infections
AssigneesThe University of North Carolina at Chapel Hill, Monash University
InventorsGauri Rao, Rajnikant Sharma, Tony Velkov, Jian Li, Varsha Thombare, Nitin Aniruddha Patil
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Abstract
Provided herein according to some embodiments a hybrid antibiotic molecule that may be resistant to multi-drug resistance. Dry powder and hydrogel formulations of the hybrid antibiotic molecules are disclosed. Also provided herein is a method of treating a bacterial infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the hybrid antibiotic molecule or a pharmaceutical composition comprising the hybrid antibiotic molecule, thereby treating the bacterial infection in the subject.
Claims24
A teixobactin-antibiotic hybrid molecule comprising teixobactin covalently linked to an antibiotic.
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Dependencies are inferred from the claim text.