Improved alum-anchored immunogens
AssigneesMassachusetts Institute of Technology, The Scripps Research Institue
InventorsDarrell IRVINE, Kristen Alexandra RODRIGUES, William R. SCHIEF
Life of this patent
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Abstract
Compositions are provided, of the general formula X1-X2-X3, wherein (a) X2 comprises an antigen; (b) X1 is absent or comprises or consists of the amino acid sequence (C)KKKTG (SEQ ID NO: 1); and (c) X3 is absent or comprises or consists of the amino acid sequence GTKKK(C) (SEQ ID NO:2), wherein (i) only one of X1 and X3 is present, and (ii) the residue m parentheses m SEQ ID NO: 1 and SEQ ID NO: 2 is optional and may be present or may be deleted.
Claims23
A composition comprising the general formula X1-X2-X3, wherein
- (a) X2 comprises a antigen;
- (b) X1 is absent or comprises or consists of the amino acid sequence (C)KKKTG (SEQ ID NO:1);
- and
- (c) X3 is absent or comprises or consists of the amino acid sequence GTKKK(C) (SEQ ID NO:2),
- wherein (i) only one of X1 and X3 is present, and (ii) the residue in parentheses in SEQ ID NO:1 and SEQ ID NO:2 is optional and may be present or may be deleted.
(canceled)
A polypeptide comprising a sequence selected from the group consisting of CGTKKK-Z1-GGSGGGS-pSer4 (SEQ ID NO:16) and pSer4-GGSGGGS-Z1-KKKTGC (SEQ ID NO:17), wherein Z1 comprises a linkage.
(canceled)
-37. (canceled)
(canceled)
-43. (canceled)
Dependencies are inferred from the claim text.