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US 2026/0295038 A1Published application
Glycolipid derivative as mincle ligand
AssigneeThe University of Osaka
InventorsSho YAMASAKI, Shigenari ISHIZUKA
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Abstract
In the present application, glycolipid derivative (I) represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof, which is useful as a novel ligand for Macrophage-inducible C-type lectin receptors, is disclosed as one of the embodiments of the invention.
Claims19
A glycolipid derivative (I) represented by the following formula (I):
- wherein
- one of R1 and R2 is a hydroxy group or a C1-6 alkoxy group, and the other is a hydrogen atom, R3 is a hydrogen atom, a hydroxy group, or a C1-6 alkoxy group,
- is a single bond (steric configuration is unspecified),
- ring S2 and ring S3 are each independently an optionally substituted pyranose or an optionally substituted deoxypyranose,
- L is a C6-14 arylene group, and
- RL is an optionally substituted C3-40 hydrocarbon group,
- or a salt thereof.
- (provided that PGL-I, PGL-II, and PGL-III (Rx and Ry of each compound are as shown in Table 1) represented by the following formula (II):
- wherein m is an integer of 13 to 21, n is an integer of 15 to 17, o is an integer of 3 to 5, p is an integer of 3 to 5, and q is an integer of 15 to 17
- are excluded from the glycolipid derivative (I)
- TABLE 1
- glycolipid derivative
- Rx
- Ry
- PGL-I
- methyl group
- methyl group
- PGL-II
- methyl group
- hydrogen atom
- PGL-III
- hydrogen atom
- methyl group).
20 more elements
A pharmaceutical composition comprising a glycolipid derivative (I′) represented by the following formula (I′):
- wherein
- one of R1 and R2 is a hydroxy group or a C1-6 alkoxy group, and the other is a hydrogen atom, R3 is a hydrogen atom, a hydroxy group, or a C1-6 alkoxy group,
- is a single bond (steric configuration is unspecified),
- ring S2 and ring S3 are each independently an optionally substituted pyranose or an optionally substituted deoxypyranose,
- L is a C6-14 arylene group, and
- RL is an optionally substituted C3-40 hydrocarbon group,
- or a salt thereof as an active ingredient
- (provided that PGL-I and PGL-II (Rx and Ry of each compound are as shown in Table 2) represented by the following formula (II):
- wherein m is an integer of 13 to 21, n is an integer of 15 to 17, o is an integer of 3 to 5, p is an integer of 3 to 5, and q is an integer of 15 to 17
- are excluded from the glycolipid derivative (I′)
- TABLE 2
- glycolipid derivative
- Rx
- Ry
- PGL-I
- methyl group
- methyl group
- PGL-II
- methyl group
- hydrogen atom).
17 more elements
-15. (canceled)
Dependencies are inferred from the claim text.