Saponin dmlt adjuvants and related uses
AssigneesQ-Vant Biosciences, Inc., The Administrators of the Tulane Educational Fund
InventorsElizabeth NORTON, Doug KLAIBER
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Abstract
A composition, preferably an immune adjuvant system, for vaccines containing a saponin component and a dmLT component. The combination of the saponin component and the dmLT component shows a synergistic effect in the treatment of various conditions, illnesses and diseases. The methods of use for prophylactic use or therapeutic treatment are disclosed. Exemplary adjuvant compositions include a double-mutant heat-labile toxin adjuvant derived from an Escherichia coli enterotoxin and a saponin, optionally with an additional vaccine component (e.g., an antigen), particularly when used in a vaccine.
Claims22
A composition comprising (i) a polymeric protein containing at least a portion of dmLT, and (ii) a saponin compound derived from Quillaja saponaria.
A method of treating of an illness, disease, or a condition, comprising administering a vaccine containing a vaccine adjuvant system comprising an effective dose of a saponin compound derived from Quillaja saponaria;
- an effective dose of at least a portion of dmLT;
- and, optionally, an effective dose of one or more vaccine components associated with the illness, disease, or condition.
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Dependencies are inferred from the claim text.