Nanoparticle-based influenza virus vaccines and uses thereof

A nucleic acid molecule encoding a fusion protein comprising:

• (a) an amino acid sequence that is at least 80%, 85%, 90%, 91%, 95%, 96%, 97%, 98%, or 99% identical, or 100% identical to a sequence selected from the group consisting of SEQ ID NO:
• 89, SEQ ID NO:245, SEQ ID NO:247, SEQ ID NO:249, SEQ ID NO:251, SEQ ID NO:
• 253, SEQ ID NO:255, and SEQ ID NO:257, joined to an immunogenic portion of an influenza virus HA protein;
• or
• (b) an amino acid sequence that is at least 80%, 85%, 90%, 91%, 95%, 96%, 97%, 98%, or 99% identical, or 100% identical to a sequence selected from the group consisting of SEQ ID NO:
• 91, SEQ ID NO:
• 93, SEQ ID NO:95, SEQ ID NO:97, SEQ ID NO:
• 99, SEQ ID NO:
• 101, SEQ ID NO:
• 103, SEQ ID NO:
• 105, SEQ ID NO:
• 107, SEQ ID NO:
• 109, SEQ ID NO:111, SEQ ID NO:
• 113, SEQ ID NO:
• 115, SEQ ID NO:117, SEQ ID NO:
• 119, SEQ ID NO:
• 121, SEQ ID NO:
• 123, SEQ ID NO:
• 125, SEQ ID NO:
• 127, SEQ ID NO:
• 129, SEQ ID NO:
• 131, SEQ ID NO:
• 133, SEQ ID NO:
• 135, SEQ ID NO:
• 137, SEQ ID NO:
• 139, SEQ ID NO:
• 141, SEQ ID NO:
• 143, SEQ ID NO:145, SEQ ID NO:
• 147, SEQ ID NO:
• 149, SEQ ID NO:
• 151, SEQ ID NO:
• 153, SEQ ID NO:
• 155, SEQ ID NO:
• 157, SEQ ID NO:
• 159, SEQ ID NO:
• 161, SEQ ID NO:
• 163, SEQ ID NO:
• 165, SEQ ID NO:
• 167, SEQ ID NO:
• 169, SEQ ID NO:
• 171, SEQ ID NO:
• 173, SEQ ID NO:
• 175, SEQ ID NO:
• 177, SEQ ID NO:
• 179, SEQ ID NO:
• 181, SEQ ID NO:
• 183, SEQ ID NO:
• 185, SEQ ID NO:
• 187, SEQ ID NO:
• 189, SEQ ID NO:
• 191, SEQ ID NO:
• 193, SEQ ID NO:
• 195, SEQ ID NO:
• 197, SEQ ID NO:
• 199, SEQ ID NO:201, SEQ ID NO:
• 203, SEQ ID NO:205, SEQ ID NO:207, SEQ ID NO:209, SEQ ID NO:211, SEQ ID NO:
• 213, SEQ ID NO:215, SEQ ID NO:217, SEQ ID NO:219, SEQ ID NO:221, SEQ ID NO:
• 223, SEQ ID NO:225, SEQ ID NO:
• 259, SEQ ID NO:261, SEQ ID NO:263, and SEQ ID NO:
• 265, and one of SEQ ID NO:340 to SEQ ID NO:346.