Combination treatments to promote epithelial integrity and treat ocular disorders
AssigneeWayne State University
InventorsElizabeth Berger, Gabriel Sosne
Life of this patent
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Abstract
Combination treatments to promote epithelial integrity and to treat ocular disorders, such as keratoepitheliopathy, impaired corneal wound healing, and corneal neuropathy, are described. The combination treatments include thymosin beta 4 (Tb4) and vasoactive intestinal peptide (VIP), or prodrugs or active fragments thereof. In various embodiments, the combination treatments can be used promote epithelial integrity and to treat ocular disorders in diabetic subjects.
Claims40
A method of promoting wound healing and/or treating an ocular condition in a subject comprising up-regulating in the subject
- thymosin beta 4 (Tb4) and/or a precursor, active fragment, or active variant thereof;
- and
- vasoactive peptide (VIP) and/or a precursor, active fragment, or active variant thereof
- thereby promoting wound healing and/or treating the ocular condition in the subject.
A composition comprising
- thymosin beta 4 (Tb4), a precursor, active fragment, and/or active variant thereof;
- and
- vasoactive peptide (VIP), a precursor, active fragment, and/or active variant thereof;
- and
- a pharmaceutically acceptable carrier.
A kit comprising
- thymosin beta 4 (Tb4), a precursor, active fragment, and/or active variant thereof;
- and
- vasoactive peptide (VIP), a precursor, active fragment, and/or active variant thereof.
Dependencies are inferred from the claim text.