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US 2026/0295008 A1Published application
Mechanical and biochemical activation and control of skeletal stem cells for cartilage regeneration
OwnerMichael T. Longaker, Charles K.F. Chan +1inventors
InventorsMichael T. Longaker, Charles K.F. Chan, Matthew P. Murphy
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Abstract
Methods and compositions are provided for the regeneration of articular cartilage by activating skeletal stem cells with a combination of (i) mechanical and (ii) biochemical stimulus. The mechanical stimulus can be an acute local injury. The biochemical stimulus can be a combination of an effective dose of a BMP2 activating agent and a VEGF inhibitor.
Claims23
A method for regenerating human articular cartilage, the method comprising:
- activating human skeletal stem cells with a combination of (i) a mechanical stimulus and (ii) a biochemical stimulus, wherein the mechanical stimulus is a surgically performed microfracture procedure to bone tissue at a desired site for articular cartilage regeneration;
- wherein the biochemical stimulus is a combination of an effective dose of human BMP2 protein and a VEGF inhibitor;
- and wherein an effective dose of exogenous stem cells are implanted at the desired site for articular cartilage regeneration.
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Dependencies are inferred from the claim text.