Back to results
US 2026/0295002 A1Published application
Gastrointestinal retentive formulations of echinocandins
AssigneeThe Cleveland Clinic Foundation
InventorThaddeus STAPPENBECK
Life of this patent
Estimating the term…
Abstract
Provided herein are methods and compositions for delivering echinocandins (e.g., caspofungin) to a subject to increase retention time in the gastrointestinal tract (e.g., to promote a localized action in the intestinal region and reduced absorption of the echinocandin) after oral administration of the composition. In certain embodiments, the compositions comprise an echinocandin and a carrier agent. In some embodiments, the compositions are used to treat fungal infections and/or inflammatory bowel disease in a subject.
Claims17
A composition comprising:
- a) an echinocandin, and
- b) a carrier agent, wherein said carrier agent comprises at least one of the following:
- i) methyl cellulose, wherein optionally said methyl cellulose comprises hydroxypropyl methyl cellulose (HPMC),
- ii) low molecular weight chitosan, optionally in acetic acid,
- iii) polyvinylpyrrolidone (PV),
- iv) Pluronic F-127, wherein said Pluronic F-127 is optionally present in said composition at about 15-17% or about 13-19%;
- v) Carbopol, wherein optionally said Carbopol is in combination with said HPMC;
- and
- vi) thermo-sensitive poloxamer (F127), optionally in combination with a pH-sensitive polyacrylic acid (PAA).
6 more elements
Dependencies are inferred from the claim text.