Use of Deep Eutectic Solvent Extract of Chinese Medicinal Herb Composition
AssigneesChloex Biotech Co., Ltd., Nanosigma Biotech. Co., Ltd.
InventorsCheng-Nan Chen, Chih-Hsien Lin
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AssigneesChloex Biotech Co., Ltd., Nanosigma Biotech. Co., Ltd.
InventorsCheng-Nan Chen, Chih-Hsien Lin
Estimating the term…
A use of a deep eutectic solvent extract of a Chinese medicinal herb composition in preparing a pharmaceutical composition with antibacterial activity is provided. The extract is obtained by performing ultrasonic extraction on the Chinese medicinal herb composition, which is composed of Artemisia argyi, Houttuynia cordata, Hedyotis diffusa, Anisomeles indica (L.) Kuntze, and Lonicera japonica, through a deep eutectic solvent and by performing a subsequent concentration process. Using a deep eutectic solvent that meets the requirements of green chemistry not only allows the active ingredients of the Chinese medicinal herb composition to be effectively extracted for use in preparing a pharmaceutical composition with antibacterial and anti-inflammatory activity, but also meets the green chemistry requirements by eliminating the need to use an organic solvent. The deep eutectic solvent is also advantageous in that it does not evaporate, has low toxicity, is biodegradable, renewable, and inexpensive, and can be easily produced.
A use of a deep eutectic solvent extract of a Chinese medicinal herb composition in preparing a pharmaceutical composition with antibacterial and anti-inflammatory activity, wherein the deep eutectic solvent extract is obtained by performing ultrasonic extraction on the Chinese medicinal herb composition through a deep eutectic solvent and by performing a concentration process after the ultrasonic extraction, the deep eutectic solvent includes betaine (Bet) as a hydrogen bond acceptor (HBA), the deep eutectic solvent further includes a hydrogen bond donor (HBD) selected from the group consisting of glycerol (Gly), lactate (LA), and mannose (MAN), and the Chinese medicinal herb composition is selected from the group consisting of a combination of Artemisia argyi, Houttuynia cordata, Hedyotis diffusa, Anisomeles indica (L.) Kuntze, and Lonicera japonica and a combination of Mentha spp, and Melaleuca alternifolia.
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