Oncolytic virus therapy
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsZongSheng Guo, David Bartlett, Zuqiang Liu, Mathilde Feist
Life of this patent
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Abstract
The presently disclosed subject matter relates to tumor infiltrated T cells induced by oncolytic virus (“OV-induced T cells”), methods of making and using said OV-induced T cells for an adoptive T-cell therapy. The presently disclosed subject matter further relates to oncolytic viruses and armed oncolytic viruses, methods of making and using said oncolytic viruses, as well as pharmaceutical compositions and kits comprising said oncolytic viruses.
Claims62
A method of treating a subject suffering from cancer, comprising:
- (a) administering, to the subject, an effective amount of an oncolytic virus to induce the infiltration of one or more T cells into the cancer;
- (b) isolating the tumor-infiltrated T cells from the cancer of the subject;
- (c) expanding the tumor-infiltrated T cells ex vivo;
- and
- (d) transferring the expanded tumor-infiltrated T cells to the subject suffering from cancer.
A method for generating tumor infiltrating oncolytic-virus induced T cells, comprising:
- (a) administering, to a subject having a cancer, an effective amount of an oncolytic virus to induce the infiltration of one or more T cells into the cancer;
- (b) isolating the tumor-infiltrated T cells from the cancer of the subject;
- and
- (c) expanding the tumor-infiltrated T cells ex vivo.
An oncolytic virus encoding a membrane-associated protein comprising an immunomodulator molecule linked to an anchoring peptide.
An oncolytic virus comprising, in its genome, a nucleic acid encoding a membrane-associated protein comprising an immunomodulator molecule linked to an anchoring peptide.
A method of treating a subject suffering from a cancer, comprising administering, to the subject, an effective amount of an oncolytic virus encoding an immunomodulator molecule.
The use of an oncolytic virus for generating tumor infiltrating oncolytic-virus induced T cells.
The use of tumor infiltrating oncolytic-virus induced T cells for treating a subject having cancer.
Dependencies are inferred from the claim text.