Method for treating lower back pain
AssigneeMesoblast International Sarl
InventorsSilviu ITESCU, Roger BROWN
Life of this patent
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Abstract
A method of treating lower back pain in a subject in need thereof, the method comprising administering to the subject a composition comprising mesenchymal lineage precursor or stem cells (MLPSCs), wherein the lower back pain is associated with an intervertebral disc that has a disc height that is not substantially reduced compared to that of an adjacent healthy disc in the subject.
Claims13
1-20. (canceled)
A method of treating lower back pain in a subject in need thereof, the method comprising administering into a nucleus pulposus or annulus fibrosus of an intervertebral disc in a subject a composition comprising allogeneic TNAP+ mesenchymal lineage precursor or stem cells (MLPSCs), wherein the lower back pain is associated
- (i) with or without contained disc herniation up to a 3 mm protrusion with no radiographic evidence of neurological compression;
- (ii) with disc height loss of less than 30% compared to a normal adjacent disc based upon radiographic evaluation;
- and
- (iii) with a visual analog scale (VAS) back pain score greater than 40;
- wherein administration of the MLSPCs is at a dose sufficient to result in at least a 50% reduction in pain as determined by (a) a visual analog scale (VAS) for at least 6 months after administration;
- and (b) a reduction of at least 15 points as determined by Oswestry Disability Index (ODI) for at least 6 months after administration.
The method claim of 21, wherein the MLPSCs are isolated by immunoselection.
Dependencies are inferred from the claim text.