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US 2026/0294926 A1Published application
Concomitant use of diazoxide in treatment
AssigneeSoleno Therapeutics, Inc.
InventorsNeil M. COWEN, Anish BHATNAGAR
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Abstract
Provided herein are methods of treating a subject in need thereof wherein diazoxide, or a pharmaceutically acceptable salt thereof, is administered concomitantly with other pharmaceuticals.
Claims27
A method of treating hyperphagia in a subject having Prader-Willi Syndrome, the method comprising:
- (a) orally administering to the subject 25 mg of diazoxide choline once daily for an initial period of four weeks;
- (b) after the initial four-week period, orally administering to the subject 50 mg of diazoxide choline once daily for a subsequent period of two weeks;
- and
- (c) after the subsequent two-week period, orally administering to the subject 75 mg of diazoxide choline once daily;
- wherein the subject is concomitantly being administered one or more strong CYP1A2 inhibitors.
2 more elements
A method of treating hyperphagia in a subject having Prader-Willi Syndrome, the method comprising:
- (a) orally administering to the subject 50 mg of diazoxide choline once daily for an initial period of two weeks;
- and
- (b) after the initial two-week period, orally administering to the subject 100 mg of diazoxide choline once daily;
- wherein the subject is concomitantly being administered one or more strong CYP1A2 inhibitors.
1 more element
A method of treating hyperphagia in a subject having Prader-Willi Syndrome, the method comprising:
- (a) orally administering to the subject 50 mg of diazoxide choline once daily for an initial period of two weeks;
- (b) after the initial two-week period, orally administering to the subject 100 mg of diazoxide choline once daily for a second two-week period;
- and
- (c) after the second two-week period, orally administering to the subject 150 mg of diazoxide choline once daily;
- wherein the subject is concomitantly being administered one or more strong CYP1A2 inhibitors.
2 more elements
A method of treating hyperphagia in a subject having Prader-Willi Syndrome, the method comprising:
- (a) orally administering to the subject a starting dosage of 100 mg of diazoxide choline once daily for an initial period of two weeks;
- (b) after the initial two-week period, orally administering to the subject a first titration dosage of diazoxide choline once daily for a second two-week period, wherein the first titration dosage is 150 mg or 200 mg of diazoxide choline;
- (c) after the second two-week period, orally administering to the subject a second titration dosage of diazoxide choline once daily for a third two-week period, wherein the second titration dosage is 200 mg, 250 mg, or 300 mg of diazoxide choline;
- and
- (d) after the third two-week period, orally administering to the subject a target maintenance dose of diazoxide choline once daily, wherein the target maintenance dose is 250 mg, 300 mg, or 325 mg of diazoxide choline;
- wherein the subject is concomitantly being administered one or more strong CYP1A2 inhibitors.
3 more elements
Dependencies are inferred from the claim text.