Neuroactive androgen receptor modulators and use thereof

Compounds of Formula I:

• or pharmaceutically acceptable salts, stereoisomers, solvates, or isotopic derivatives thereof, wherein:
• R1 and R2 are each independently cyano, halogen, C1-C6 haloalkyl, nitro, or —NR5R6;
• R3 and R4 are each independently hydrogen, cyano, halogen, C1-C6 haloalkyl, nitro, —NR5R6, —C(O)C1-C6 alkyl, —N(R7)C(O)C1-C6 alkyl, —N(R7)C(O)—C1-C6 haloalkyl, —C1-C6 alkyl-C(O)C1-C6 alkyl, —S(O)2—C1-C6 alkyl, —N(R7)—S(O)2—C1-C6 alkyl, C1-C6 alkyl, or C1-C6 alkoxy;
• W is CH or N;
• L is a bond, —C(O)—, —C(O)O—, —S(O)2—, or —C(O)NH—;
• R is hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 3- to 12-membered heterocyclyl, 3- to 12-membered heterocyclyl-C1-C6 alkyl, 5- to 12-membered heteroaryl, —C1-C6 alkyl-NR5R6, glucosyl, or amino acid, wherein the heterocyclyl and heteroaryl contain 1 or 2 heteroatoms each independently selected from N, O, or S, and the cycloalkyl, aryl, heterocyclyl, and heteroaryl are optionally substituted by 1 or 2 substituents each independently selected from C1-C6 alkyl, C1-C6 alkoxy, halogen, and cyano;
• and
• R5, R6 and R7 are each independently hydrogen or C1-C6 alkyl.