Composition for treating ototoxic hearing loss caused by aminoglycoside antibiotics
AssigneesKyungpook National University Industry-Academic Cooperation Foundation, Kyungpook National University Hospital, Industry-Academic Coorperation Foundation Daegu Haany University
InventorsUn-Kyung KIM, Ye-Ri KIM, Kyu-Yup LEE, Jeong-In BAEK
Life of this patent
Estimating the term…
Abstract
The present invention relates to a pharmaceutical composition for preventing or treating hearing loss, the composition containing berberine chloride as an active ingredient, wherein the pharmaceutical composition was found to effectively inhibit hair cell apoptosis caused by reactive oxygen species and exhibit an excellent protective effect on hair cells, and thus can be effectively used as a drug or health supplement for preventing or treating hearing loss.
Claims9
A method of preventing or treating an ototoxic hearing loss caused by an aminoglycoside drug, comprising:
- administering a pharmaceutical composition comprising berberine chloride as an active ingredient to a subject.
A combination of antimicrobial agents, comprising berberine chloride and an aminoglycoside drug.
A method of preventing or ameliorating an ototoxic hearing loss caused by an aminoglycoside drug, comprising:
- administering a health functional food composition comprising berberine chloride as an active ingredient to a subject.
Dependencies are inferred from the claim text.