Compositions comprising modulators of ribonucleoprotein granule formation and dissolution and methods of use thereof

A method for treating a symptom of a disease or infection in a subject in need thereof, wherein the method comprises administering to the subject an effective amount of a sulfonyl triazole compound of Formula (I):

• wherein:
• X1 and X2 are each CH or N, subject to the proviso that when X1 is CH, X2 is N and when X1 is N, X2 is CH;
• R1 is selected from alkyl, cycloalkyl, aralkyl, aryl, and substituted aryl;
• and
• R2 is selected from alkyl, substituted alkyl, aralkyl, substituted aralkyl, aryl, and substituted aryl, wherein said administrating modulates the formation of pathological ribonucleoprotein granules (RNPGs).

A composition for use in treating a symptom associated with a viral infection, cancer, or a neurological disease, wherein the composition comprises a compound of Formula (I):

• wherein:
• X1 and X2 are each CH or N, subject to the proviso that when X1 is CH, X2 is N and when X1 is N, X2 is CH;
• R1 is selected from alkyl, cycloalkyl, aralkyl, aryl, and substituted aryl;
• and
• R2 is selected from alkyl, substituted alkyl, aralkyl, substituted aralkyl, aryl, and substituted aryl, wherein said administrating modulates the formation of pathological ribonucleoprotein granules (RNPGs).