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OwnerMandar V. Shah, Kumaresan Parthasarathi +3inventors
InventorsMANDAR V. SHAH, KUMARESAN PARTHASARATHI, ILANGO SUBRAMANIAN, VEERAPPAN SUBRAMANIAN, AMAN TREHAN
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This invention provides novel compositions comprising an anti-inflammatory agent and a mydriatic agent suitable for intraocular use, particularly ketorolac or pharmaceutically salts thereof and phenylephrine or pharmaceutically salts thereof, which are free of any buffering agent and yet, surprisingly, maintain stability for significant periods of time (e.g., at least about 3 months). The present invention also relates to a process of preparing such compositions and use thereof, e.g., in combination with intraocular ophthalmologic irrigation solutions.
A method for maintaining pupil size during cataract surgery or intraocular lens replacement comprising administration to one or both eyes of a patient a pharmaceutically acceptable and ophthalmologically suitable composition (1) that comprises (a) a therapeutically effective amount of a pharmaceutically acceptable salt of ketorolac, (b) a therapeutically effective amount of a pharmaceutically acceptable salt of phenylephrine, and (c) an ophthalmologically acceptable carrier, (2) wherein the composition lacks a buffer, and (3) wherein the composition comprises less than 0.5% of total impurities.
Dependencies are inferred from the claim text.