Levothyroxine dispersions
AssigneesMaia Pharmaceuticals, Inc., Maiaresearch India Private Limited
InventorsSrikanth SUNDARAM, Riyaz Ahammad SHAIK, Lakshmikantha Reddy PONNAPUREDDY
Life of this patent
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Abstract
The present invention relates to pharmaceutical dispersions comprising levothyroxine or its pharmaceutically acceptable salts which is primarily dispersed (e.g., primarily suspended) in a pharmaceutically acceptable carrier. These levothyroxine pharmaceutical dispersions can be long-acting and are useful in treating and/or preventing myxedema coma, hypothyroidism, and/or other thyroid disorders.
Claims32
A long-acting parenteral pharmaceutical dispersion comprising (a) a therapeutically effective amount of levothyroxine or a pharmaceutically acceptable salt thereof, wherein the levothyroxine or its pharmaceutically acceptable salt is primarily dispersed in a pharmaceutically acceptable liquid carrier and (b) one or more pharmaceutically acceptable excipients.
8-9. (canceled)
14-15. (canceled)
17-21. (canceled)
23-26. (canceled)
A pharmaceutical dispersion comprising (a) levothyroxine or its pharmaceutically acceptable salt dispersed in a mixture of water and one or more non-aqueous solvents, (b) surfactant, (c) tonicity agent, (d) one or more buffers, (e) stabilizing agent, (f) suspending agent, (g) optionally viscosity enhancing agent (h) optionally chelating agent, and (i) optionally one or more pH adjusting agents.
(canceled)
36-38. (canceled)
A process for preparing sterile levothyroxine or its pharmaceutically acceptable salt comprising
- a) dissolving levothyroxine or its pharmaceutically acceptable salt in a suitable liquid medium to form a solution,
- b) sterilizing the solution from step (a), and
- c) isolating the sterile levothyroxine or its pharmaceutically acceptable salt.
41-42. (canceled)
A freeze dried long-acting composition comprising a therapeutically effective amount of levothyroxine or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients.
Dependencies are inferred from the claim text.