Methods for treating gastrointestinal inflammatory diseases using alpha-ketoglutarate (akg) modulators
OwnerAlmudena Chavez, Scott Loweinventors
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Abstract
The present disclosure provides methods and compositions for treating or preventing a gastrointestinal inflammatory disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent that increases alpha-ketoglutarate (aKG) expression and/or activity.
Claims25
A method for treating or preventing a gastrointestinal inflammatory disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent that increases alpha-ketoglutarate (αKG) expression and/or activity.
A method for selecting a subject suffering from a gastrointestinal inflammatory disease for treatment with an agent that increases alpha-ketoglutarate (αKG) activity comprising
- a. detecting OGDH mRNA and/or OGDH polypeptide levels in a biological sample obtained from the patient that are elevated relative to a predetermined threshold or a reference sample obtained from a healthy control subject;
- and
- b. administering to the subject an effective amount of an agent that increases αKG activity.
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A method for enhancing tissue regeneration in a subject that has received radiation therapy comprising administering to the subject a therapeutically effective amount of alpha-ketoglutarate (αKG) or glutamine.
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Dependencies are inferred from the claim text.