Reduced coenzyme q10 composition and production method for the same
AssigneeKaneka Corporation
InventorsSubaru Tanizaki, Tsuyoshi Matsuno, Takao Yamaguchi
Life of this patent
Estimating the term…
Abstract
A reduced coenzyme Q10 composition in which transition to other crystal forms is unlikely is provided. The reduced coenzyme Q10 composition includes reduced coenzyme Q10, decaprenylphenol, and reduced coenzyme Q9. The peak area ratio (decaprenylphenol/RQ9) of a peak containing decaprenylphenol having a relative retention time (RRT) relative to a retention time (RT) of a peak top of the reduced coenzyme Q10 of 1.34 to 1.41 to a peak containing the reduced coenzyme Q9 (RQ9) having the relative retention time (RRT) of 0.69 to 0.73 in a chromatogram of the composition is 0.1 to 10.0.
Claims20
A reduced coenzyme Q10 composition comprising:
- reduced coenzyme Q10,
- decaprenylphenol, and
- reduced coenzyme Q9 (RQ9),
- wherein a peak area ratio (decaprenylphenol/RQ9) of a peak containing the decaprenylphenol having a relative retention time (RRT) relative to a retention time (RT) of a peak top of the reduced coenzyme Q10 of 1.34 to 1.41 to a peak containing the reduced coenzyme Q9 (RQ9) having the relative retention time (RRT) of 0.69 to 0.73 in a chromatogram of the composition is 0.1 to 10.0,
- wherein the chromatogram is obtained by high performance liquid chromatography under conditions in which:
- a column is a C18 column that is 150 mm in length and 4.6 mm in inner diameter,
- a mobile phase composition is CH3OH:C6H14 at 9:1 (v/v),
- a mobile phase flow rate is 1 mL/min, and
- a detection wavelength is 190 nm.
A production method of reduced coenzyme Q10 composition comprising:
- separating, from a solution comprising reduced coenzyme Q10, decaprenylphenol, and reduced coenzyme Q9, a composition in solid form comprising the reduced coenzyme Q10, the decaprenylphenol, and the reduced coenzyme Q9,
- wherein a peak area ratio (decaprenylphenol/RQ9) of a peak containing the decaprenylphenol having a relative retention time (RRT) relative to a retention time (RT) of a peak top of the reduced coenzyme Q10 of 1.34 to 1.41 to a peak containing the reduced coenzyme Q9 (RQ9) having the relative retention time (RRT) of 0.69 to 0.73 in a chromatogram of the composition is 0.1 to 10.0,
- wherein the chromatogram of the composition after the separation is obtained by high performance liquid chromatography under conditions in which
- a column is a C18 column that is 150 mm in length and 4.6 mm in inner diameter,
- a mobile phase composition is CH3OH:C6H14 at 9:1 (v/v),
- a mobile phase flow rate is 1 mL/min, and
- a detection wavelength is 190 nm.
Dependencies are inferred from the claim text.