Compositions and methods using thymol and/or carvacrol for induction of autophagy
AssigneeSociete des Produits Nestle S.A.
InventorsJEROME FEIGE, PHILIPP GUT, GABRIELE CIVILETTO, FEDERICO SIZZANO
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Abstract
Compositions and methods can use a combination of thymol and/or carvacrol, optionally with high protein for induction of autophagy in an individual in need thereof. Preferably, a formulation containing a combination of thymol and/or carvacrol, optionally with protein is administered to the individual in an amount effective to induce autophagy, for example in muscle. The formulation can concomitantly promote protein synthesis and removal of damaged cellular materials.
Claims12
A method for treatment, prevention or management of cellular malfunction, genome damage, or a disease or condition associated with altered mitochondrial function or reduced mitochondrial density, the method comprising administering a composition comprising at least one component selected from the group consisting of thymol and carvacrol to an individual in need thereof.
A method comprising administering a composition comprising a combination of an autophagy inducer and high protein, the composition is administered to provide an amount of the combination that concomitantly promotes protein synthesis and removal of damaged cellular materials to an individual in need thereof.
A method of achieving at least one result selected from the group consisting of (i) an increased level of LC3-II protein expression or turnover, (ii) an increased level of the LC3-II/LC3-I protein ratio, (iii) a decreased level of p62 protein, (iv) a decreased level of a protein of the autophagosome, (v) an increased level of mRNA expression of an autophagy-related gene, (vi) an increased number and/or size and/or intensity of LC3 positive puncta, and (vii) degradation of LC3 and/or another autophagosome protein, the method comprising administering a therapeutically effective amount of a composition comprising a combination of an autophagy inducer and high protein to an individual in need thereof.
Dependencies are inferred from the claim text.