Remote control and quantitative monitoring of drug release from nanoparticles based on magnetic particle imaging
AssigneeBoard of Trustees of Michigan State University
InventorsBryan SMITH, Yapei ZHANG
Life of this patent
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Abstract
A method for targeting and tuning drug release in a human or non-human subject includes monitoring release of one or more drugs from one or more nanocomposites administered to the subject and applying precision-controlled optical stimulus to an area of the subject hosting the one or more nanocomposites to accelerate release of the one or more drugs from the one or more nanocomposites.
Claims20
A method for targeting and tuning in vivo drug release in a human or non-human subject, the method comprising:
- monitoring release of one or more drugs from one or more nanocomposites administered to the subject, the monitoring including:
- collecting information regarding the release of the one or more drugs from the one or more nanocomposites, and
- analyzing the collected information to determine if a concentration of the released one or more drugs is within a therapeutic window;
- and
- applying precision-controlled optical stimulus to an area of the subject hosting the one or more nanocomposites to accelerate release of the one or more drugs from the one or more nanocomposites when the concentration of the released one or more drugs is below the therapeutic window.
(canceled)
A method for targeting and tuning in vivo drug release in a human or non-human subject, the method comprising:
- collecting information regarding release of one or more drugs from one or more nanocomposites administered to a subject;
- determining, using the collected information, if a concentration of the released one or more drugs is outside of a therapeutic window;
- if the concentration of the released one or more drugs is within the therapeutic window, continuing to collect information regarding the release of the one or more drugs from the one or more nanocomposites;
- and
- if the concentration of the released one or more drugs is below the therapeutic window, causing a precision-controlled optical stimulus to be applied to an area of the subject hosting the one or more nanocomposites for a period greater than or equal to about 1 minute to less than or equal to about 20 minutes to accelerate the release of the one or more drugs from the one or more nanocomposites.
A method for targeting and tuning in vivo drug release in a human or non-human subject, the method comprising:
- collecting information regarding release of one or more drugs from one or more nanocomposites administered to a subject using magnetic particle imaging, intensity of magnetic particle imaging signals varying in response to the release of the one or more drugs;
- determining, using the collected information, if a concentration of the released one or more drugs is below a therapeutic window;
- if the concentration of the released one or more drugs is within the therapeutic window, continuing to collect information regarding the release of the one or more drugs from the one or more nanocomposites;
- and
- if the concentration of the released one or more drugs is outside of the therapeutic window, using near-infrared light irradiation to accelerate the release of the one or more drugs from the one or more nanocomposites, the near-infrared light irradiation applied to an area of the subject hosting the one or more nanocomposites.
Dependencies are inferred from the claim text.