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US 2026/0294832 A1Published application
Polymer nanoparticle compositions for non-viral gene delivery
OwnerAndrea D. McCue, Kenneth R. Sims, Jr. +5inventors
InventorsAndrea D. McCue, Kenneth R. Sims, Jr., Danielle J. Huk, Jacqueline Grible, Ashlee J. Colbert, Emma K. Schmitz, Anthony D. Duong
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Abstract
The disclosure relates to block copolymer nanoparticles for therapeutic delivery of nucleic acids, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering RNAs.
Claims20
A block copolymer comprising
- a first block comprising a first homopolymer of monomer units of formula I:
- or a salt thereof, wherein:
- p is 0 or an integer selected from 1-3,
- wherein the * represent the connecting points to the rest of the block copolymer;
- and
- a second block comprising a second homopolymer of monomer units of formula II:
- or a salt thereof, wherein:
- R1 is alkyl;
- and
- wherein each * represents a connecting point to the rest of the block copolymer,
- wherein the first block has a molecular weight (Mn) of at least about 15 kDa, and
- wherein the block copolymer has a ratio of monomer units of formula I to monomer units of formula II of about 80:20 to about 99:1.
9 more elements
Dependencies are inferred from the claim text.