Gluconic acid-coated selenium nanoparticles and manufacturing method thereof, and pharmaceutical composition comprising the selenium nanoparticle and applications thereof

Abstract

The present invention provides a gluconic acid-coated selenium nanoparticle (GA-SeNP), which comprises a selenium nanoparticle and gluconic acid, wherein the gluconic acid is coated on the selenium nanoparticle to form a core-shell structure. GA-SeNPs can repolarize M2 macrophages into M1 macrophages and induce apoptosis of cancer cells through the generation of reactive oxygen species, thereby serving as the medicine for cancer treatment. A manufacturing method thereof is also provided.

Dependencies are inferred from the claim text.