Antidiabetic pharmaceutical composition

Abstract

A pharmaceutical composition includes therapeutic nanoparticles including a core including insulin, a shell comprising chitosan, the shell disposed on the core, and a coating containing pectin and dextrin on the shell, and a pharmaceutically acceptable carrier and/or excipient. A method of forming the pharmaceutical composition includes adding a sodium tri-polyphosphate solution to a chitosan solution including the chitosan and acetic acid while stirring to form a shell solution, mixing a dextrin solution with an insulin solution to form a core solution, forming a pectin solution, mixing the shell solution, the core solution, and the pectin solution using a homogenizer to form a precursor mixture, aging the precursor mixture to form the nanoparticles, and mixing the nanoparticles with the pharmaceutically acceptable carrier and/or excipient.

Dependencies are inferred from the claim text.