Back to results
US 2026/0294818 A1Published application
Reconstitutable dry powder formulations and methods of use thereof
OwnerAshish SARODE, Shrirang KARVE +1inventors
InventorsAshish SARODE, Shrirang KARVE, Priyal PATEL
Life of this patent
Estimating the term…
Abstract
The present disclosure is directed to the use of reconstituted mRNA dry powder particles for parenteral administration. The present disclosure is also directed to a method of generating dry powder particles supplemented with appropriate excipients for optimal thermostability and in vivo expression.
Claims39
A dry powder formulation for reconstitution comprising:
- (a) an excipient that is sucrose or trehalose;
- and
- (b) a lipid nanoparticle (LNP) comprising a messenger RNA (mRNA) encapsulated by one or more lipids;
- wherein the excipient of (a) and total lipids in the LNP of (b) have a weight ratio of at least about 5.
1 more element
A dry powder formulation for reconstitution comprising
- (a) an excipient that is a sugar or sugar alcohol;
- and
- (b) a lipid nanoparticle (LNP) comprising a messenger RNA (mRNA) encapsulated by one or more lipids;
- wherein weight ratio of the excipient of (a) to total lipids in the LNP of (b) is at least about 5.
1 more element
A method of preparing a dry powder formulation for reconstitution, the method comprising:
- (a) combining a first mixture comprising lipid nanoparticles (LNPs) and an ethanolic solution, thereby obtaining a second mixture, wherein the LNPs comprise a messenger RNA (mRNA) encapsulated by one or more lipids, and wherein the ethanolic solution comprises an excipient that is sucrose or trehalose at a concentration of about 1-11% w/v, and
- (b) spray-drying the second mixture, thereby obtaining the dry powder formulation.
Dependencies are inferred from the claim text.