Ionizable lipid compound, lipid carrier comprising same, and application
AssigneeInnovec Biotherapeutics
InventorsXinghua PAN, Cheng WANG
Life of this patent
Estimating the term…
Abstract
The present invention relates to an ionizable lipid compound, a lipid carrier comprising same, and an application of the ionizable lipid compound. The present invention provides a series of compounds as shown in formula (1), a lipid carrier comprising same as an ionizable lipid, a nucleic acid lipid nanoparticle composition, and a preparation thereof. Lipid nanoparticles formed by the ionizable lipid can deliver nucleic acid molecules into cells, thus increasing the transfer rate of the nucleic acid molecules, and thereby improving the treatment effect of a nucleic acid drug.
Claims20
A compound represented by formula (1) or a pharmaceutically acceptable salt thereof:
- wherein
- A is —O—CO—NH— or —NH—CO—O—;
- G1 and G2 are independently C1-4 alkylene;
- R1 and R2 are independently -G3-O—C(═O)—R5, -G3-C(═O)—O—R5, -G3-NH—C(═O)—O—R5, -G3-NH—O—C(═O)—R5, -G3-NH—C(═O)—R5 or -G3-O—C(═O)—NH—R5;
- G3 is independently C2-10 alkylene;
- R5 is C2-30 alkyl or C2-30 alkenyl, and said alkyl or alkenyl is optionally substituted with one or more of —O—C1-30 alkyl, —C(═O)—O—C1-30 alkyl, —O—C(═O)—C1-30 alkyl, —O—C2-30 alkenyl, —C(═O)—O—C2-30 alkenyl or —O—C(═O)—C2-30 alkenyl;
- and
- R3 and R4 are independently C1-8 alkyl.
A compound or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the following compounds:
- Structure of Compound
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 16
- 17
- 18
- 19
- 20
- 21
- 22
- 23
- 24
- 25
- 26
- 27
Dependencies are inferred from the claim text.