Biomimetic proteolipid nanovesicles for delivery of nucleic acids

Abstract

Disclosed herein is a biomimetic proteolipid nanovesicle, comprising: an ionizable or cationic lipid; a phosphocholine-based phospholipid; a cholesterol; a leukocyte membrane protein; and an siRNA encapsulated by the biomimetic proteolipid nanovesicle; wherein the biomimetic proteolipid nanovesicle has a lipid-to-protein ratio of from about 1:65 to about 1:85 by weight. Further disclosed herein is a biomimetic proteolipid nanovesicle, comprising: an ionizable or cationic lipid; a phosphocholine-based phospholipid; a cholesterol; a leukocyte membrane protein; and an mRNA encapsulated by the biomimetic proteolipid nanovesicle; wherein the biomimetic proteolipid nanovesicle has a lipid-to-protein ratio of from about 1:80 to about 1:100 by weight.

Dependencies are inferred from the claim text.