US 2026/0294805 A1 · PROGRAMMABLY DEGRADABLE HYDROGELS FOR FUNCTIONAL MOLECULAR RELEASE

Abstract

Disclosed herein are compositions including polymers functionalized with oxanorbornadiene (“OND”) crosslinkers and various within, where the materials and formulations thereof enable controlled, extended release of cargos such as therapeutic, antigenic, diagnostic, and/or analytical agents. Also disclosed is the use of physical entrapment of the cargo, covalent connection of the cargo to polymer via cleavable linkages, and combinations thereof. These combinations provide different patterns and durations of release of cargo molecules. Also disclosed herein are the methods of making and using the same.

Claims33

Dependent claims

A composition comprising a crosslinked network obtained by crosslinking a mixture comprising a multi-valent nucleophile-terminated compound and a first polymer functionalized with oxanorbornene groups of Formula (1):

wherein:
Ra and Rb together form an epoxide or double bond;
R1 is selected from H, halo, C1-4alkyl, C1-4haloalkyl, C0-4alkC6-12aryl, C0-4alkC3-12heteroaryl, and -L-polymer;
R4 is selected from H, halo, C1-4alkyl, C1-4haloalkyl, C0-4alkC6-12aryl, C0-4alkC3-12heteroaryl, and -L-polymer;
Ra′ is selected from H, halo, C1-4alkyl, C1-4haloalkyl, C0-4alkC6-12aryl, C0-4alkC3-12heteroaryl, and -L-polymer;
Rb′ is selected from H, halo, C1-4alkyl, C1-4haloalkyl, C0-4alkC6-12aryl, C0-4alkC3-12heteroaryl, and -L-polymer;
R2 is selected from trifluoromethyl, cyano, nitro, C(═O)Rc, C(═O)ORc, C(═O)NHRc, and C(═O)N(Rc)2;
R3 is selected from trifluoromethyl, cyano, nitro, C(═O)Rd, C(═O)ORd, C(═O)NHRd, and C(═O)N(Rd)2;
Rc and Rd are independently a C1-4alkyl group, C0-4alkC6-12aryl, or -L-polymer, or Rc and Rd together form a ring;
L is a linker;
and
the oxanorbornene is substituted by a single -L-polymer group.

9 more elements

Dependencies are inferred from the claim text.

Facts

Application

19/476,958Filed 22 Apr 2024

Priority

20 Apr 2023

Published

1 Oct 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61K 9/06
Medicinal preparations characterised by special physical form: ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
A61K 39/12
Medicinal preparations containing antigens or antibodies: viral antigens
A61K 39/385
Medicinal preparations containing antigens or antibodies: haptens or antigens, bound to carriers
A61K 47/10
Containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides: alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene…

Abstract

Claims33

Dependent claims

wherein:
Ra and Rb together form an epoxide or double bond;
R1 is selected from H, halo, C1-4alkyl, C1-4haloalkyl, C0-4alkC6-12aryl, C0-4alkC3-12heteroaryl, and -L-polymer;
R4 is selected from H, halo, C1-4alkyl, C1-4haloalkyl, C0-4alkC6-12aryl, C0-4alkC3-12heteroaryl, and -L-polymer;
Ra′ is selected from H, halo, C1-4alkyl, C1-4haloalkyl, C0-4alkC6-12aryl, C0-4alkC3-12heteroaryl, and -L-polymer;
Rb′ is selected from H, halo, C1-4alkyl, C1-4haloalkyl, C0-4alkC6-12aryl, C0-4alkC3-12heteroaryl, and -L-polymer;
R2 is selected from trifluoromethyl, cyano, nitro, C(═O)Rc, C(═O)ORc, C(═O)NHRc, and C(═O)N(Rc)2;
R3 is selected from trifluoromethyl, cyano, nitro, C(═O)Rd, C(═O)ORd, C(═O)NHRd, and C(═O)N(Rd)2;
Rc and Rd are independently a C1-4alkyl group, C0-4alkC6-12aryl, or -L-polymer, or Rc and Rd together form a ring;
L is a linker;
and
the oxanorbornene is substituted by a single -L-polymer group.

9 more elements

Dependencies are inferred from the claim text.

Programmably degradable hydrogels for functional molecular release

Life of this patent

Abstract

Claims33

Programmably degradable hydrogels for functional molecular release

Life of this patent

Abstract

Claims33