Dissolvable microneedle delivery systems for bioactive compounds

Abstract

A dissolvable microneedle (DMN) system is provided for the transdermal, intradermal, topical, or transmucosal delivery of bioactive compounds. Each microneedle is formed from a biocompatible, biodegradable material that dissolves upon contact with interstitial or mucosal fluid, enabling localized or systemic administration. The system supports a range of bioactive agents, including vitamins, minerals, peptides, proteins, amino acids, antioxidants, algae-derived compounds, plant-derived volatile compounds, and synthetic molecules, including those encapsulated in nanocarriers such as lipid nanoparticles, liposomes, or polymeric systems. Microneedle arrays may be fabricated in customizable sizes and geometries, including layered or tip-loaded structures. The invention addresses challenges related to poor bioavailability, compound instability, or patient compliance associated with oral or injectable routes. Applications include therapeutic, cosmetic, veterinary, nutraceutical, and agricultural use. The system enables controlled, sustained, or biphasic release of sensitive compounds and expands delivery to populations with swallowing difficulties, malabsorption, or needle aversion, offering a versatile, minimally invasive platform for precision bioactive administration.

Dependencies are inferred from the claim text.