Bio-adhesive materials with cationic surface peptide
AssigneeMiyoshi America, Inc.
InventorsShoji TAKEKAWA, Ryo Ohara
Life of this patent
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Abstract
The present disclosure relates generally to bio-adhesive materials having a surface containing one or more cationic surface peptides, formulations containing the materials, and methods of making a material comprising one or more cationic surface peptides on the surface thereof comprising contacting the substrate material with at least one cationic surface peptide to immobilize the at least one cationic surface peptide to the surface of the substrate material. The materials have superior bio-adhesion to biological substrates, reduced aggregation, can be used in formulations without significant aggregation of the materials, and can be used without the need to add a hydrophobic surface treatment, or a film-forming ingredient.
Claims20
A bioadhesive substance comprising at least one substrate material in which the surface of the at least one substrate material is chemically modified with at least one cationic surface peptide, wherein the at least one cationic surface peptide is chemically immobilized on the surface of at least one substrate material by a multivalent metal ion.
A method of making a surface-modified bioadhesive substance comprising:
- (a) preparing an aqueous dispersion of at least one substrate material;
- (b) adding to the aqueous dispersion at least one cationic surface peptide with agitation to uniformly disperse the mixture and form a substrate and peptide dispersion;
- and
- (c) adding a multivalent metal-containing salt to neutralize the substrate and peptide dispersion and immobilize the at least one cationic surface peptide on the surface of the at least one substrate material.
A cosmetic composition comprising:
- (a) at least one bioadhesive substance comprising at least one substrate material in which the surface of the at least one substrate material is chemically modified with at least one cationic surface peptide, wherein the at least one cationic surface peptide is chemically immobilized on the surface of at least one substrate material by a multivalent metal ion;
- and
- (b) a cosmetically acceptable carrier.
Dependencies are inferred from the claim text.