Segmented calcium phosphate bone scaffolds with sacrificial zones for mechano-transductive bone regeneration and methods of making and using the same
AssigneeBoard of Regents, The University of Texas System
InventorsTeja Guda, Anson Joo Leng Ong, Gennifer Chiou
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Abstract
This application describes scaffolds, particularly bone scaffolds, with localized changes in mechanical properties allowing for re-introduced stalled bone regeneration within critical sized defects. Utilizing mechanical stiffness and scaffold degradation initiated mechano-transductive pathways re-activates bone regeneration activity. Localized changes in mechanical properties in spatial and temporally controlled manner reinduces stalled bone regeneration.
Claims19
A bone scaffold comprising at least a first segment comprising a slow-dissolving calcium phosphate (CaP) scaffold and at least a second sacrificial segment comprising a fast dissolving CaP scaffold, wherein the at least second sacrificial segment degrades and/or swells when exposed to aqueous fluid environments over a defined time course.
A method of producing a segmented bone scaffold comprising:
- printing at least a first segment using a first ink material having a first fluid dissolution rate when cured, and
- printing at least a second sacrificial segment using a second ink material having a second fluid dissolution rate when cured,
- wherein the bone scaffold is contiguous having structural continuity between the at least first and at least second sacrificial segments.
Dependencies are inferred from the claim text.