Sensor for analyte monitoring with drug-eluting capabilities

A method of manufacturing a sensor for measurement of an analyte in a medium within a living animal, the method comprising:

• providing first drug-eluting material in or on a first drug portion of an exterior surface of a housing of the sensor, wherein:
• the exterior surface of the housing comprises an indicator portion, the first drug portion on a first side of the indicator portion, and a second drug portion on a second side of the indicator portion that is opposite the first side of the indicator portion;
• the sensor includes circuitry within the housing, the circuitry comprises a sensing area that includes one or more light sources and one or more photodetectors, and the indicator portion of the housing corresponds to the sensing area of the circuitry;
• the sensor includes analyte indicator material on or in only the indicator portion of the exterior surface of the housing;
• the analyte indicator material comprises indicator molecules configured to reversibly bind the analyte, and the indicator molecules have a detectable property indicative of whether the analyte is bound or unbound;
• the one or more lights sources of the sensing area are configured to emit light to the analyte indicator material;
• and
• the one or more photodetectors of the sensing area are configured to receive light reflected from or emitted by the analyte indicator material;
• and
• providing second drug-eluting material in or on the second drug portion of the exterior surface of the housing, wherein the first and second drug-eluting material each comprise one or more therapeutic agents that reduce deterioration of the analyte indicator material.