Methods for detecting tumor disease states using conjugates including volatile organic compounds
AssigneeVerily Life Sciences LLC
InventorsBenjamin Krasnow, Kristopher Lavery, Sarah Sanowar, Eric Paoli
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Abstract
The present disclosure is related to methods and compositions related to detecting a tumor disease state in a subject using a sample of the subject's exhaled breath. A conjugate is administered to the subject, wherein the conjugate includes a tumor targeting moiety linked to a volatile organic compound (VOC). The presence or amount of the VOC is detected as an indication of the disease state.
Claims24
A method for detecting a tumor disease state, comprising:
- (a) contacting a tissue of interest with a conjugate including a tumor targeting moiety linked to a volatile organic compound, wherein tumor targeting moiety has affinity and specificity for tumor cells, wherein the volatile organic compound is a non-naturally occurring volatile organic compound;
- and
- (b) measuring an amount of the volatile organic compound present in exhaled breath, wherein the amount of the volatile organic compound in exhaled breath is indicative of an amount of tumor cells present at the tissue of interest.
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A method for detecting a tumor disease state, comprising:
- (a) administering a composition to a subject, the composition comprising a conjugate including a tumor targeting moiety linked to a volatile organic compound by a linking group;
- (b) causing the volatile organic compound to separate from the conjugate;
- (c) obtaining a breath sample from the subject;
- (d) measuring an amount of volatile organic compound separated from the conjugate;
- and
- (e) determining the tumor disease state in the subject, wherein an amount of volatile organic compound separated from the conjugate is correlated to the tumor disease state.
A method of detecting a tumor disease state using a subject's breath, comprising:
- (a) administering a composition to a subject, the composition comprising a conjugate including a tumor targeting moiety linked to a volatile organic compound;
- (b) obtaining a breath sample from the subject;
- (c) providing the breath sample to a breath detector apparatus including a breath volatile organic compound analyzer;
- and
- (d) measuring, using the breath volatile organic compound analyzer, an amount of the volatile organic compound.
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Dependencies are inferred from the claim text.