Apparatus and methods for capturing non-volatile and semi-volatile substances from breath
AssigneeCannabix Technologies Inc.
InventorsJared BOOCK, Mikko MÄÄTTÄ, Rajpaul ATTARIWALA
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Abstract
Methods and apparatus for capturing exhaled aerosols containing a target analyte of interest from breath, retaining the exhaled aerosols including the target analyte of interest in droplet form, and allowing the target analyte of interest to be desolvated directly from the droplet. The apparatus can use a filamentous substrate to capture the exhaled droplets.
Claims36
A method of analyzing for a presence of a target substance in breath of a subject, the method comprising the steps of:
- collecting a breath sample from the subject;
- allowing aerosol droplets containing both water and the target substance to collect on a collection medium;
- prior to or during the step of collecting the aerosol droplets, coalescing the aerosol droplets;
- and
- desolvating the aerosol droplets from the collection medium for further analysis, wherein the target substance comprises non-volatile or semi-volatile molecules.
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A method of collecting a target substance from a breath of a subject, the method comprising the steps of:
- collecting a breath sample from the subject;
- allowing aerosol droplets containing both water and the target substance to collect on a collection medium;
- and
- retaining the aerosol droplets in a liquid form.
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An apparatus for collecting aerosol droplets containing a target substance from breath, the apparatus comprising:
- a mouthpiece;
- a collection cartridge in fluid communication with the mouthpiece;
- and
- a filamentous substrate for collecting the aerosol droplets, the filamentous substrate being contained within the collection cartridge;
- and
- a puck sealingly interposing the collection cartridge and the mouthpiece, the puck comprising one or more knife-like ridges at a downstream end of the puck;
- wherein the target substance comprises non-volatile or semi-volatile molecules.
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An apparatus for collecting aerosol droplets containing a target substance from breath, the apparatus comprising:
- a mouthpiece;
- a collection cartridge in fluid communication with the mouthpiece;
- a filamentous substrate for collecting the aerosol droplets, the filamentous substrate being contained within the collection cartridge;
- and
- a droplet diverter positioned to promote coalescence of aerosol droplets from a breath sample;
- wherein the target substance comprises non-volatile or semi-volatile molecules.
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Dependencies are inferred from the claim text.