System and method for non-invasive determination of intracranial pressure

A system for determining intracranial pressure non-invasively, comprising:

• a contact lens;
• at least one force transducer for controllably applying at least one selected force to an eye of a subject;
• a camera for imaging retinal vascular pulsation of an eye of the subject over at least one cardiac cycle at the at least one selected force;
• a control module for controlling the force applied to the eye by the force transducers;
• and
• a processing module for determining intracranial pressure (ICP) of the subject, the processing module being configured to:
• receive the retinal vascular pulsation images from the camera;
• process the retinal vascular pulsation images to produce retinal vascular pulsation amplitude data as a time-varying signal at the at least one selected force;
• decompose the time-varying signal into at least two frequency components representing the time-varying signal;
• and
• determine an intracranial pressure from a data basis which includes at least information associated with the frequency components;
• and
• wherein retinal vascular pulsation data includes at least retinal arterial pulsation data.

A non-invasive intracranial pressure-determining computer software product configured to:

• receive retinal vascular pulsation images from a camera of an ODF device;
• receive controlled selected force information applied to the eye or associated pressure data;
• process the retinal vascular pulsation images to produce retinal vascular pulsation amplitude data as a time-varying signal;
• decompose the time-varying signal into at least two frequency components representing the time-varying signal;
• determine an intracranial pressure from a data basis which includes at least one of the coefficients associated with the frequency components;
• and
• wherein the retinal vascular pulsation data includes at least retinal arterial pulsation data.

One or more non-transitory computer readable media having computer readable instructions thereon that, upon execution by at least one processor, cause the at least one processor to:

• process retinal vascular pulsation images of an eye of a subject to produce retinal vascular pulsation amplitude data as a time-varying signal, the retinal vascular pulsation images being obtained via imaging the eye of the subject over at least one cardiac cycle during application of at least one selected controlled force to the eye of the subject;
• decompose the time-varying signal into at least two frequency components representing the time-varying signal at each one of multiple locations having different distances relative to the centre of the eye of the subject;
• prepare a data basis comprising, for at least two different distances relative to the centre of the eye, at least information associated with the at least two frequency components of the retinal vascular pulsation amplitude data;
• and
• determine intracranial pressure of the subject non-invasively from the data basis.

A system for determining intracranial pressure non-invasively, the system comprising:

• at least one force transducer for controllably applying at least one selected force to an eye of a subject;
• an imaging device for imaging retinal vascular pulsation of an eye of the subject over at least one cardiac cycle at the at least one selected force;
• a control module for controlling the force applied to the eye by the force transducers;
• and
• one or more non-transitory computer readable media having computer readable instructions thereon that are executable for determining intracranial pressure (ICP) of a subject, wherein the instructions, upon execution by at least one processor, cause the at least one processor to:
• process images of the retinal vascular pulsation obtained via the imaging device to produce retinal vascular pulsation amplitude data as a time-varying signal at the at least one selected force;
• decompose the time-varying signal into at least two frequency components representing the time-varying signal;
• and
• determine an intracranial pressure from a data basis which includes at least information associated with the frequency components;
• and
• wherein retinal vascular pulsation amplitude data includes at least retinal arterial pulsation data, wherein the data basis comprises a frequency domain characterization of the time varying signal for the retinal vascular pulsation amplitude data at different distances relative to a center of an optic nerve of the eye of the subject.

A method of determining an intracranial pressure (ICP) of a subject non-invasively, the method comprising:

• imaging retinal vascular pulsation of an eye of the subject over at least one cardiac cycle at application of at least one selected controlled force to the eye of the subject;
• processing the retinal vascular pulsation images to produce retinal vascular pulsation amplitude data as a time-varying signal;
• decomposing the time-varying signal into at least two frequency components representing the time-varying signal;
• and
• determining intracranial pressure from a data basis which comprises at least information associated with the frequency components,
• wherein the retinal vascular pulsation amplitude data comprises at least retinal arterial pulsation data recorded at multiple locations of a recorded segment of an artery or vein of the eye of the subject.

One or more non-transitory computer readable media having computer readable instructions thereon that, upon execution by at least one processor, cause the at least one processor to:

• process retinal vascular pulsation images of an eye of a subject to produce retinal vascular pulsation amplitude data as a time-varying signal, the retinal vascular pulsation images being obtained via imaging the eye of the subject over at least one cardiac cycle during application of at least one selected controlled force to the eye of the subject;
• convert the time-varying signal into a frequency domain signal including transforming the time-varying signal into at least two frequency components representing the time-varying signal at different distances relative to the centre of the eye of the subject;
• prepare a data basis comprising, for at least two different distances relative to the centre of the eye, information associated with the at least two frequency components of the retinal vascular pulsation amplitude data;
• and
• determine intracranial pressure of the subject non-invasively from the data basis.