Non-invasive central venous pressure monitoring device
AssigneeHadasit Medical Research Services and Development Ltd.
InventorsOffer AMIR, Haytam KASEM, Kareem ABD-RBO, Aiman ABU AMMAR, Dean NACHMAN
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Abstract
This invention relates to a method and system for non-invasively monitoring central venous pressure, using a set of microneedles and micro-electromechanical systems, e.g., in heart failure. Herein, the microneedle-based sensor attaches to the skin at the neck of a subject to monitor central venous pressure, as it is a direct representative of filling pressures causing skin sub-surface strain.
Claims20
A device for essentially non-invasively monitoring a subject's central venous pressure comprising:
- a microneedle structure comprising a first surface, a second surface opposing said first surface, and a plurality of microneedles attached to or being an integral part of said first surface, wherein the plurality of microneedles is configured to penetrate a skin surface at a target area above and/or in vicinity to the subject's central vein;
- and at least one sensor associated with or incorporated within the microneedle structure, wherein the at least one sensor comprises a polymer,
- wherein the at least one sensor is configured to provide signals indicative of the central venous pressure.
A system for essentially non-invasively monitoring a subject's central venous pressure, the system comprising:
- a microneedle structure comprising a first surface and a second surface opposing said first surface, wherein the microneedle structure further comprises a plurality of microneedles attached to or integrated within the first surface thereof, and wherein the plurality of microneedles is configured to penetrate a skin surface at an area above and/or in vicinity to the subject's central vein;
- at least one sensor associated with or incorporated within the microneedles and/or the microneedle structure, wherein the at least one sensor comprises a polymer, wherein the at least one sensor is configured to provide pressure indicative signals;
- and
- a patient data acquisition processing system configured to receive data from the at least one sensor and to apply trained algorithms on the received pressure signals, and to provide values indicative of the central venous pressure of the subject.
A method for essentially non-invasively monitoring the central venous pressure of a subject, the method comprising:
- placing a central venous pressure monitoring device to the subject's skin surface at an area above and/or in vicinity to the subject's central vein, wherein the device comprises:
- a microneedle structure comprising a first surface, a second surface opposing said first surface, and a plurality of microneedles attached to or being an integral part of the first surface thereof;
- and
- at least one sensor in association with or incorporated within the microneedles and/or the microneedle structure, wherein the at least one sensor comprises a polymer;
- piercing the skin surface with the microneedles;
- measuring skin deformation with the at least one sensor;
- obtaining, using a data acquisition processing system, skin deformation related signals;
- applying, using the data acquisition processing system, trained algorithms on the received signals;
- and
- providing values indicative of the central venous pressure of the subject, based on the obtained signals and the trained algorithms.
Dependencies are inferred from the claim text.