Mouse model with humanized telomere
AssigneeWashington State Univesity
InventorsJiyue ZHU, Shuwen WANG, Fan ZHANG, De CHENG
Life of this patent
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Abstract
The present disclosure provides a transgenic mouse as well as associated methods thereof for use as a mouse model. The transgenic mouse described herein comprises a humanized mouse telomerase (hmTert) gene contained in a background murine germline that provides shortened telomeres that can replicate humans and various human disease states.
Claims35
A transgenic mouse comprising i) a background murine germline and ii) a humanized mouse telomerase (hmTert) gene contained in the background murine germline.
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A method for evaluating a treatment, the method comprising steps of i) administering the treatment to a transgenic mouse and ii) analyzing a response to the treatment in the transgenic mouse, wherein the response provides evaluation of the treatment.
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A method of generating a transgenic mouse, the method comprising steps of:
- inserting an hmTert gene into a background murine germline to form a modified embryonic stem cell;
- and
- generating a first-generation mouse from the modified embryonic stem cell, wherein the first-generation mouse comprises the hmTert gene.
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Dependencies are inferred from the claim text.