Diagnosis method using cell free nucleosome levels

A method for diagnosing the presence or the risk of development of a disorder of hemostasis or thrombosis or of monitoring the progress of a disorder of hemostasis or thrombosis in a subject suffering from the condition, comprising:

• (i) contacting a body fluid sample obtained from the subject with a binding agent to detect or measure the level of cell free nucleosomes or a component thereof;
• (ii) repeating step (i) on one or more occasions;
• and
• (iii) using any changes in the level of cell free nucleosomes or component thereof to monitor the progression of the disorder of hemostasis or thrombosis in the subject.

A method of assigning a risk of an adverse outcome to a subject suffering from a disorder of hemostasis or thrombosis comprising:

• (i) contacting a body fluid sample obtained from the subject with a binding agent to detect or measure the level of cell free nucleosomes or a component thereof;
• and
• (ii) using the level of cell free nucleosomes detected to assign the likelihood of an adverse outcome to said subject,
• wherein a subject identified with a high likelihood of an adverse outcome is assigned for medical intervention.